Cell-substrate interaction : A method for evaluating the possible correlation between metastatic phenotype and cell surface energy |
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| Authors: | S Reich H Rosin M Levy R Karkash A Raz |
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| Institution: | 1. Department of Plastic Research, The Weizmann Institute of Science, Rehovot 76100, Israel;2. Department of Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel |
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| Abstract: | The interfacial energy of the non-attached to substrate cell surface was analysed in tumor cell variants of the K-1735 melanoma and UV-2237 fibrosarcoma series, which exhibit distinct metastatic phenotypes. The highly metastatic cell variants exhibited a two-fold increase in the ability to form rapid cell substrate interactions, as compared with their low-metastatic counterparts. These results further highlight the possible role of cell adhesiveness in the process of metastasis. |
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| Keywords: | To whom offprint requests should be sent Address: Department of Cell Biology The Weizmann Institute of Science P O Box 26 Rehovot 76100 Israel |
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