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Chromatin modulation and the DNA damage response
Authors:Costelloe Thomas  Fitzgerald Jennifer  Murphy Niall J  Flaus Andrew  Lowndes Noel F
Institution:Genome Stability Laboratory, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway.
Abstract:The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.
Keywords:DNA  Chromatin  DNA damage response  Histone
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