Effects of deprivation of two essential amino acids on DNA synthesis in chinese hamster cells |
| |
Authors: | LP Everhart |
| |
Institution: | Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colo. 80302, USA |
| |
Abstract: | The effects of isoleucine deprivation on DNA synthesis were compared with leucine deprivation. Omission of either amino acid prevented entry of G1 cells into S. Cells deprived of isoleucine were able to complete S although the rate of DNA synthesis decreased steadily after deprivation. The effects of leucine deprivation were more drastic and not all cells were able to complete S. It is proposed that isoleucine deprivation results in G1 arrest because S phase cells are less sensitive to its omission than to the omission of other amino acids. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|