Diethanolamine Pd(II) complexes in bioorganic modeling as model systems of metallopeptidases and soybean lipoxygenase inhibitors |
| |
| Authors: | Zorica D Petrovi&#x; Dimitra Hadjipavlou-Litina Eleni Pontiki Du&#x;ica Simijonovi&#x; Vladimir P Petrovi&#x; |
| |
| Institution: | aDepartment of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, P.O. Box 60, 34000 Kragujevac, Serbia;bDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece |
| |
| Abstract: | The reaction of PdCl2 with diethanolammonium chloride (DEAxHCl), in the molar ratio 1:2, affords the HDEA]2PdCl4] complex (1). The hydrolytic activity of the novel Pd(II) complex 1 was tested in reaction with N-acetylated L-histidylglycine dipeptide (AcHis-Gly). Complex 1, as well as earlier prepared trans-PdCl2(DEA)2] complex (2), and DEA, as their precursor, were tested for their in vitro free radical scavenging activity. UV absorbance-based enzyme assays were done in order to evaluate their inhibitory activity of soybean lipoxygenase (LOX). Also, assays with superoxide anion radical were done. The scavenging activities of the complexes were measured and compared with those of their precursors and caffeic acid. Complex 2 exhibits the highest antioxidant activity and the highest inhibitory effect against the soybean LOX. |
| |
| Keywords: | Palladium(II) complex Structure Hydrolytic activity Soybean lipoxygenase inhibitors Free radical scavenger activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
