Strophasterols E and F: Rearranged ergostane-type sterols from Pleurotus eryngii |
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| Institution: | 1. Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan;2. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People’s Republic of China;3. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China;1. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China;2. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, PR China;3. School of Life Sciences and Biomedical Center, Sun Yat-Sen University, Guangzhou 510275, PR China;4. Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand;1. Helmholtz Centre for Infection Research GmbH, Department Microbial Drugs, Inhoffenstraße 7, 38124 Braunschweig, Germany;2. German Centre for Infection Research Association (DZIF), partner site Hannover-Braunschweig, Inhoffenstraße 7, 38124 Braunschweig, Germany;3. Helmholtz Centre for Infection Research GmbH, Department Cellular Proteome Research, Inhoffenstraße 7, 38124 Braunschweig, Germany;4. Departamento de Ingeniería del Medio Agronómico y Forestal, Universidad de Extremadura, Badajoz, Spain;5. Institute of Microbiology, Technical University of Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany;1. Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, PR China;2. College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China;3. Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China;1. Guangdong Institute of Microbiology, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou, China;2. Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China |
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| Abstract: | Strophasterols E (1) and F (2) were isolated from the fruiting bodies of Pleurotus eryngii, together with four new ergostane-type sterols (3–6). Single-crystal X-ray diffraction analysis performed on the tris-p-bromobenzoate derivatives of compounds 1 and 2 allowed these two compounds to be identified as the structurally rare (22S,23R)- and (22S,23S)-5α,6α-epoxy-3β,7β,23-trihydroxy-15(14 → 22)-abeo-ergost-8-en-14-one, respectively. The inhibitory effects on nitric oxide production of the six new steroids thus isolated from the fruiting bodies of P. eryngii were also evaluated. |
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| Keywords: | Steroid Ergostane Nitric oxide production inhibitor |
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