The relationship between interleukin-6 in saliva,venous and capillary plasma,at rest and in response to exercise |
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| Institution: | 1. Cardiff School of Sport, Cardiff Metropolitan University, Cardiff CF23 6XD, UK;2. Cardiff School of Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UK;1. Department of Urology, New York University Langone Medical Center, New York, New York;2. Nephrology Division, New York University Langone Medical Center, New York, New York;3. Divisions of Comparative Effectiveness and Decision Science, New York University Langone Medical Center, New York, New York;4. Division of Biostatistics, Department of Population Health, New York University Langone Medical Center, New York, New York;5. Section of Urology, New York Harbor Veterans Affairs Healthcare System, New York, New York;6. Nephrology Section, New York Harbor Veterans Affairs Healthcare System, New York, New York;1. School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, 200032, China;2. Shanghai Huangpu Center for Disease Prevention and Control, Shanghai, 200001, China;3. Children’s Hospital of Fudan University, National Center for Children’s Health, Shanghai, 201102, China;1. Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany;2. Department of Pedriatric Rheumatology & Immunology, University Children’s Hospital Münster, 48149 Münster, Germany;3. Department of General, Visceral and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany;4. Clinical Research and Development, Department of Anesthesiology, University of Colorado, Aurora, CO 80045-7503, USA;5. Department of Biopsychology, Faculty of Psychology, Ruhr-University Bochum, 44780 Bochum, Germany;1. Stress Research Institute, Department of Psychology, Stockholm University, SE-106 91, Stockholm, Sweden;2. Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;3. Osher Center for Integrative Medicine, ME Neuroradiologi, Karolinska Universitetssjukhuset, Stockholm, Sweden;1. Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland;2. Institute of Dentistry, University of Turku, Lemminkaisenkatu 2, 20520 Turku, Finland;3. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany;4. Department of Pathology, Turku University Hospital, Kiinamyllynkatu 4-8, 20521 Turku, Finland |
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| Abstract: | IL-6 plays a mechanistic role in conditions such as metabolic syndrome, chronic fatigue syndrome and clinical depression and also plays a major role in inflammatory and immune responses to exercise. The purpose of this study was to investigate the levels of resting and post exercise IL-6 when measured in venous plasma, saliva and capillary plasma. Five male and five females completed 2 separate exercise trials, both of which involved standardized exercise sessions on a cycle ergometer. Venous blood and saliva samples were taken immediately before and after Trial A, venous and capillary blood samples were taken immediately before and after Trial B. IL-6 values were obtained using a high-sensitivity enzyme-linked immunosorbent assay (ELISA). In Trial A venous plasma IL-6 increased significantly from 0.4 ± 0.14 pg/ml to 0.99 ± 0.29 pg/ml (P < 0.01) while there was no increase in salivary IL-6. Venous plasma and salivary IL-6 responses were not correlated at rest, post exercise or when expressed as an exercise induced change. In Trial B venous and capillary plasma IL-6 increased significantly (venous: 0.22 ± 0.18 to 0.74 ± 0.28 pg/ml (P ⩽ 0.01); capillary: 0.37 ± 0.22 to 1.08 ± 0.30 pg/ml (P < 0.01). Venous and capillary plasma responses did not correlate at rest (r = 0.59, P = 0.07) but did correlate post exercise (r = 0.79, P ⩾ 0.001) and when expressed as an exercise induced change (r = 0.71, P = 0.02). Saliva does not appear to reflect systemic IL-6 responses, either at rest or in response to exercise. Conversely, capillary plasma responses are reflective of systemic IL-6 responses to exercise. |
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| Keywords: | Interluekin-6 Cytokines Exercise Capillary Saliva |
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