The ?251A>T polymorphism of interleukin-8 is associated with longer mechanical ventilation and hospital staying after coronary surgery |
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| Institution: | 1. Department of Cardiology, Koc University School of Medicine and Hospital, Istanbul, Turkey;2. Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey;3. Duzen Laboratory, Cemal Sahir Sok. No: 14, 34383 Mecidiyekoy, Istanbul, Turkey;1. Department of Emergency Medicine, New Haven, CT, United States of America;2. Department of Internal Medicine (Section of Nephrology), New Haven, CT, United States of America;3. Department of Internal Medicine (Section of Cardiology), New Haven, CT, United States of America;4. Yale Center for Analytical Sciences, New Haven, CT, United States of America;1. Department of Food Science and Human Nutrition, Agricultural University of Athens, Athens, Greece;2. Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA;3. Department of Cardiology, “Elpis” General Hospital of Athens, Athens, Greece;4. Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, University Campus, Thessaloniki, Greece;5. First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece;6. Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University, Athens, Greece |
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| Abstract: | Background: Cardiac surgery is associated with inflammatory responses that are known to affect its outcome. The present study was designed to define whether post-operative release of interleukin (IL)-6, 8 and tumor necrosis factor-alpha (TNF-α) is related to the presence of a certain allele in functional polymorphism and its relationship to clinical outcome after off-pump coronary artery bypass (OPCAB). Methods: One hundred and forty-five patients undergoing first time elective OPCAB were genotyped for IL-6(?174G>C), IL-8(?251A>T) and TNF-α(?308G>A) polymorphisms using polymerase chain reaction (PCR) and gene sequencing. Cytokine levels were measured in plasma samples taken before the operation and 4, 24 and 72 h postoperatively by suspension array system. Results: Levels of IL-6 and IL-8 increased significantly after OPCAB. Patients with IL-6?174GG and IL-8?251AA genotypes had higher post-operative circulating levels of IL-6 and IL-8, respectively. Logistic regression showed that IL-8?251AA genotype was an independent risk factor of ventilation time more than 1 day (OR = 11.80, 95% CI: 1.87–74.48) and hospital staying more than 14 days (OR = 38.00, 95% CI: 4.15–347.87) after surgery. Conclusions: OPCAB results in post-operative inflammatory responses. Genetic backgrounds alter the extent of inflammatory response and might relate to clinical outcome of OPCAB. |
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