Cu(II) ion interaction with teicoplanin-vancomycin’s analog |
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Authors: | Magdalena Brzezowska Francesca Bernardi Nicola Gaggelli Gianni Valensin |
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Institution: | a Faculty of Chemistry, University of Wroc?aw, F. Joliot-Curie 14, 50-383 Wroc?aw, Poland b Department of Chemistry, University of Siena, Via Aldo Moro, 53100 Siena, Italy |
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Abstract: | Teicoplanin, a member of the “last chance” antibiotic family has a similar structure and the same mechanism of action as parent drug vancomycin, which is proved to be an effective binder of Cu(II) ions. However, the potentiometric and spectroscopic studies (UV-visible, CD, NMR) have shown that the modification of the N-terminal structure of the peptide backbone in teicoplanin affects considerably the binding ability towards Cu(II) ions. While vancomycin forms almost instantly the stable 3 N complex species involving the N-terminal and two amide nitrogen donors, in case of teicoplanin only two nitrogen donors derived from the N-terminal amino group and adjacent peptide bond are coordinated to Cu(II) ion within the whole pH range studied. The major factor influencing the binding mode is most likely the structure of the N-terminus of the peptide unit in the antibiotic ligand. |
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Keywords: | Glycopeptide antibiotics Teicoplanin Copper coordination |
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