Reactivation of herpes simplex virus in a cell line inducible for simian virus 40 synthesis |
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| Authors: | G B Zamansky L F Kleinman P H Black J C Kaplan |
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| Institution: | Department of Medicine, Massachusetts General Hospital and Departments of Microbiology and Molecular Genetics, and Medicine, Harvard Medical School, Boston, MA 02114, U.S.A. |
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| Abstract: | The reactivation of UV-irradiated herpes simplex virus (HSV) was investigated in irradiated and unirradiated transformed hamster cells in which infectious simian virus 40 (SV40) can be induced. Reactivation was enhanced when the cells were treated with UV light or mitomycin C prior to infection with HSV. The IV dose-response curve of this enhanced reactivation was strikingly similar to that found for induction of SV40 virus synthesis in cells treated under identical condictions. This is the first time that two SOS functions described in bacteria have been demonstrated in a single mammalian cell line. |
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| Keywords: | Send reprint request to Glen B Zamansky Laboratory of Radiobiology Department of Physiology Harvard University School of Public Health 665 Huntington Avenue Boston MA 02115 U S A |
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