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The exchange hypothesis for the formation of chromatid aberrations: an experimental test using bleomycin |
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| Authors: | A M Duncan H J Evans |
| Institution: | MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU Great Britain |
| Abstract: | The association between bleomycin-induced chromatid aberrations and BUdR-label exchange between sister chromatids was investigated in order to evaluate Revell's exchange hypothesis for the formation of chromatid aberrations. The results of this study indicate that a larger than expected proportion of chromatid breaks can be accounted for by the exchange hypothesis though not all breaks are the result of incomplete exchange. |
| Keywords: | Present address to which all correspondence should be sent: Ludwig Institute for Cancer Research Toronto Branch 9 Earl Street Toronto Ohio M4Y 1M4 Canada |
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