Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy |
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Authors: | Hana Demova Jana Boleckova Daniela Rose Hannes Koeppel Bohumir Prochazka Ludmila Brunerova Ivan Rychlik Marie Cerna |
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Institution: | 1.Department of General Biology and Genetics, 3rd Faculty of Medicine,Charles University,Prague,Czech Republic;2.5th Medical Department, Medical Faculty Mannheim,University Heidelberg,Mannheim,Germany;3.Department of Scientific Information and Biostatistics,National Institute of Public Health,Prague,Czech Republic;4.2nd Department of Internal Medicine, 3rd Faculty of Medicine,Charles University,Prague,Czech Republic |
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Abstract: | A considerable variability in the incidence and prevalence of diabetic nephropathy (DN) coheres with an important contribution
of multigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic
nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other
diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic
origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism
in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism
and the T/C (−786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic
nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting
enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients
the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism
in the eNOS gene is associated with metabolic syndrome including type 2 diabetes. |
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