Matricellular proteins and inflammatory cells: A task force to promote or defeat cancer? |
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Authors: | Andrea Sabina Llera Maria Romina Girotti Lorena Gabriela Benedetti Osvaldo Luis Podhajcer |
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Institution: | 1. Department of Cardiology, Higahi-osaka City General Hospital, 3-4-5 Nishi Iwata, Higashi-osaka, Osaka 578-8588, Japan;2. Division of Cardiovascular Medicine and Coronary Heart Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan |
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Abstract: | In the last years it became clear that the tumor microenvironment plays a major role in neoplastic growth. Proteins secreted either by the malignant cells or by the tumor-associated stromal cells act as extracellular signal transductors, orchestrating tumor progression. Sentinel cells of the innate immune system patrol the different organs and have proven either to promote tumor growth or induce tumor suppression. In recent years, members of the matricellular family of extracellular proteins were shown to be involved in different aspects of the inflammatory response during tumor development, although in contradictory ways. In this review we discuss the evidence available up to date that relates matricellular proteins with the regulation of the inflammatory response and tumor progression. |
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