Antimicrobial potentials and structural disorder of human and animal defensins |
| |
| Institution: | 1. Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah, Saudi Arabia;2. Cell Biology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Gizza, P.O. Box 12622, Egypt;3. Department of Molecular Medicine and USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA;4. Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russian Federation, Russia;5. Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications, New Borg EL-Arab 21934, Alexandria, Egypt;1. Biology Centre, Institute of Parasitology, Academy of Sciences of the Czech Republic, Brani?ovská 31, 370 05 ?eské Budějovice, Czech Republic;2. University of South Bohemia, Faculty of Science, Brani?ovská 31, 370 05 ?eské Budějovice, Czech Republic;3. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo náměstí 2, 166 10 Prague 6, Czech Republic;1. Department of Medical Microbiology and Immunobiology University of Szeged, Dom ter 10, Szeged 6725, Hungary;2. Department of Psychiatry Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Kálvária Ave 57, Szeged 6724, Hungary;3. Department of Neurology Faculty of Medicine Albert Szent-Györgyi Clinical Centre University of Szeged, Semmelweis u. 6, Szeged 6725 Hungary;4. Department of Neurology and Cerebrovascular Diseases Pándy Kálmán County Hospital, Semmelweis u. 5, Gyula 5700 Hungary;1. Integrated Biotherapeutics, Inc., Rockville, MD 20850, USA;1. CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India;2. Virupaksha Life Sciences Pvt Ltd, CRTDH, CSIR-Centre for Cellular and Molecular Biology Annexe-II, Hyderabad 500 007, India;3. National Population and Family Planning Commission Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China;8. Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China;12. Shanghai Key Laboratory for Molecular Andrology, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;4. College of Life Sciences, Northwest University, Taibai North Road 229, Xi''an, Shaanxi 710069, China;5. School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Road, Nanjing 210009, China;6. East China University of Science and Technology, Shanghai 200237, China |
| |
| Abstract: | Defensins are moonlighting peptides which are broadly distributed throughout all the living kingdoms. They play a multitude of important roles in human health and disease, possessing several immunoregulatory functions and manifesting broad antimicrobial activities against viruses, bacteria, and fungi. Based on their patterns of intramolecular disulfide bridges, these small cysteine-rich cationic proteins are divided into three major types, α-, β-, and θ-defensins, with the α- and β-defensins being further subdivided into a number of subtypes. The various roles played by the defensins in the innate (especially mucosal) and adoptive immunities place these polypeptides at the frontiers of the defense against the microbial invasions. Current work analyzes the antimicrobial activities of human and animal defensins in light of their intrinsic disorder propensities. |
| |
| Keywords: | Defensins Antimicrobial peptides Anti-tumor activity Protein structure protein function Intrinsic disorder |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
