A critical role of interleukin-1 in preterm labor |
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| Institution: | 1. Departments of Pediatrics, Ophthalmology and Pharmacology, CHU Sainte-Justine Research Center, Montréal H3T 1C5, Canada;2. Department of Pharmacology, Université de Montréal, Montréal H3C 3J7, Canada;3. Department of Chemistry, Université de Montréal, Montréal, Québec H3C 3J7, Canada;4. Departments of Obstetrics and Gynecology, Pediatrics and Physiology, University of Alberta, Edmonton AB TG6 2S2, Canada;5. Departments of Obstetrics and Gynecology, CHU Sainte-Justine Research Centre, Montréal H3T 1C5, Canada;1. Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK;2. Clinical Immunology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden;1. Department of Obstetrics and Gynecology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic;2. Biomedical Research Center, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic;3. Department of Obstetrics and Gynecology, University Hospital in Ostrava, Ostrava, Czech Republic;4. Department of Obstetrics and Gynecology, Faculty of Medicine, Ostrava University, Ostrava, Czech Republic;5. BCNatal–Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), Fetal i+D Fetal Medicine Research Center, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Centre for Biomedical Research on Rare Diseases (Centro de Investigación Biomédica en Red Enfermedades Raras), Barcelona, Spain;6. Department of Obstetrics and Gynecology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden;7. Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;1. Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, China;2. School of Public Health of Guangxi Medical University, Nanning 530021, Guangxi, China;3. Department of Nutrition and Food Hygiene, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China;4. Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China;5. Department of Medical Services Section, Maternal & Child Health Hospital of Yulin, Yulin 537000, Guangxi, China;6. Department of Surgery, Maternal & Child Health Hospital of Qinzhou, Qinzhou 535000, Guangxi, China;7. Department of Gynecology and Obstetrics, Maternal & Child Health Hospital of Guigang, Guigang 537100, Guangxi, China;8. Department of Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China;9. Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China;10. Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China;1. Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing, China;2. Beijing Key Laboratory of Maternal Foetal Medicine of Gestational Diabetes Mellitus, Beijing, China;3. Peking University, Beijing, China;1. Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield, Sheffield, UK;2. Integrated BioSciences Group, School of Clinical Dentistry, The University of Sheffield, Sheffield, UK;1. Department of Obstetrics and Gynecology, The Ohio State College of Medicine, Columbus, OH, USA;2. Center for Perinatal Research, Nationwide Children’s Hospital, Columbus, OH, USA;3. Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA;4. Program in Human Genetics, Vanderbilt University Medical Center, Nashville, TN, USA |
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| Abstract: | Preterm birth (PTB) is a leading cause of neonatal mortality and morbidity worldwide, and represents a heavy economic and social burden. Despite its broad etiology, PTB has been firmly linked to inflammatory processes. Pro-inflammatory cytokines are produced in gestational tissues in response to stressors and can prematurely induce uterine activation, which precedes the onset of preterm labor. Of all cytokines implicated, interleukin (IL)-1 has been largely studied, revealing a central role in preterm labor. However, currently approved IL-1-targeting therapies have failed to show expected efficacy in pre-clinical studies of preterm labor. Herein, we (a) summarize animal and human studies in which IL-1 or IL-1-targeting therapeutics are implicated with preterm labor, (b) focus on novel IL-1-targeting therapies and diagnostic tests, and (c) develop the case for commercialization and translation means to hasten their development. |
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| Keywords: | Preterm birth Preterm labor Interleukin-1 Inflammation Infection |
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