Cyclophilin a plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by spinoculation |
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| Authors: | Saphire Andrew C S Bobardt Michael D Gallay Philippe A |
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| Institution: | Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA. |
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| Abstract: | Cyclophilin A (CypA) is necessary for effective human immunodeficiency virus type 1 (HIV-1) replication. However, the functions of CypA and the precise steps at which CypA acts in the HIV-1 life cycle remain to be determined. By using a methodology that bypasses the need for attachment factors-spinoculation-we present evidence that CypA participates in both entry and postentry events. |
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