The Epstein-Barr Virus BDLF4 Gene Is Required for Efficient Expression of Viral Late Lytic Genes |
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| Authors: | Takahiro Watanabe Yohei Narita Masahiro Yoshida Yoshitaka Sato Fumi Goshima Hiroshi Kimura Takayuki Murata |
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| Institution: | Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan |
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| Abstract: | Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression. |
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