Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection |
| |
Authors: | Soares Rui Foxall Russell Albuquerque Adriana Cortesão Catarina Garcia Miguel Victorino Rui M M Sousa Ana E |
| |
Institution: | Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal. |
| |
Abstract: | CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|