Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation |
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| Authors: | Johnson R P Lifson J D Czajak S C Cole K S Manson K H Glickman R Yang J Montefiori D C Montelaro R Wyand M S Desrosiers R C |
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| Institution: | New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA. |
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| Abstract: | Three different deletion mutants of simian immunodeficiency virus (SIV) that vary in their levels of attenuation were tested for the ability to protect against mucosal challenge with pathogenic SIV. Four female rhesus monkeys were vaccinated by intravenous inoculation with SIVmac239Delta3, four with SIVmac239Delta3X, and four with SIVmac239Delta4. These three vaccine strains exhibit increasing levels of attenuation: Delta3 < Delta3X
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