Comparative Virus Replication and Host Innate Responses in Human Cells Infected with Three Prevalent Clades (2.3.4, 2.3.2, and 7) of Highly Pathogenic Avian Influenza H5N1 Viruses |
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| Authors: | Honglei Sun Yipeng Sun Juan Pu Yi Zhang Qingyu Zhu Jing Li Jiang Gu Kin-Chow Chang Jinhua Liu |
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| Institution: | aKey Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China;bState Key Laboratory of Pathogens and Bio-security, Academy of Military Medical Sciences, Beijing, China;cDepartment of Pathology, Shantou University Medical College, Shantou, China;dSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, United Kingdom |
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| Abstract: | Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2, and 7 are the dominant cocirculating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clade 2.3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4-infected macrophages caused the most severe cellular damage and strongest proinflammatory response. |
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