Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease |
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Authors: | Knizewski Lukasz Kinch Lisa Grishin Nick V Rychlewski Leszek Ginalski Krzysztof |
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Institution: | Łukasz Kniżewski, Lisa Kinch, Nick V. Grishin, Leszek Rychlewski, and Krzysztof Ginalski |
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Abstract: | Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle. |
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