首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Apoptosis induced by tumor necrosis factor in cells chronically infected with feline immunodeficiency virus.
Authors:K Ohno  T Nakano  Y Matsumoto  T Watari  R Goitsuka  H Nakayama  H Tsujimoto  and A Hasegawa
Abstract:Tumor necrosis factor alpha (TNF-alpha) induced morphologic changes such as chromatin condensation and cell shrinkage in a feline fibroblastic cell line (CRFK) chronically infected with feline immunodeficiency virus (FIV) but not in uninfected CRFK cells. DNA extracted from TNF-alpha-treated CRFK cells infected with FIV showed a ladder of nucleosomal DNA, indicating that this cytocidal effect by TNF-alpha was due to programmed cell death, or apoptosis. These findings may have implications for understanding the pathogenesis of FIV infection and for the design of specific therapeutic strategies for AIDS in humans as well as cats.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号