Acute Clearance of Human Metapneumovirus Occurs Independently of Natural Killer Cells |
| |
| Authors: | Sherry C Wen Sharon J Tollefson Monika Johnson Pavlo Gilchuk Kelli L Boyd Bryan Shepherd Sebastian Joyce John V Williams |
| |
| Institution: | aDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee;bDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee;cDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee |
| |
| Abstract: | Human metapneumovirus (HMPV) is a major cause of respiratory disease. The role of NK cells in protection against HMPV is unclear. We show that while HMPV-infected C57BL/6 mice had higher numbers of functional lung NK cells than mock-treated mice, comparing NK cell-depleted and control mice did not reveal differences in lung viral titers, histopathology, cytokine levels, or T cell numbers or function. These data indicate that NK cells are not required for host control of HMPV. |
| |
| Keywords: | |
|
|
