Functional Similarity between E6 Proteins of Cutaneous Human Papillomaviruses and the Adenovirus E1A Tumor-Restraining Module |
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Authors: | Mohan Kuppuswamy T Subramanian Elizabeth Kostas-Polston S Vijayalingam Ling-jun Zhao Mark Varvares G Chinnadurai |
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Institution: | Institute for Molecular Virology, Saint Louis University School of Medicine, Doisy Research Center, St. Louis, Missouri, USAa;Saint Louis University Cancer Center, St. Louis, Missouri, USAb |
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Abstract: | The adenovirus E1A C-terminal region restrains oncogenic transformation through interaction with three distinct cellular protein complexes that include the DYRK1A/1B/HAN11 complex. The E6 proteins of beta-human papillomaviruses (beta-HPVs) also interact with the DYRK1/HAN11 complex. A variant of HPV5 E6 frequently found in epidermodysplasia verruciformis skin lesions interacted less efficiently with DYRK1A/HAN11. The E6 variant and E7 of HPV5 efficiently coimmortalized primary epithelial cells, suggesting that naturally arising variants may contribute potential oncogenic activities of beta-HPV E6 proteins. |
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