Infectious Bursal Disease Virus VP3 Upregulates VP1-Mediated RNA-Dependent RNA Replication |
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| Authors: | Diego Ferrero Damià Garriga Aitor Navarro José F Rodríguez Núria Verdaguer |
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| Institution: | aCentro Nacional de Biotecnología (CSIC), Cantoblanco, Madrid, Spain;bInstitut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain;cMRC-University of Glasgow, Centre for Virus Research, Glasgow, Scotland, United Kingdom |
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| Abstract: | Genome replication is a critical step in virus life cycles. Here, we analyzed the role of the infectious bursal disease virus (IBDV) VP3, a major component of IBDV ribonucleoprotein complexes, on the regulation of VP1, the virus-encoded RNA-dependent RNA polymerase (RdRp). Data show that VP3, as well as a peptide mimicking its C-terminal domain, efficiently stimulates the ability of VP1 to replicate synthetic single-stranded RNA templates containing the 3′ untranslated regions (UTRs) from the IBDV genome segments. |
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