Canine Distemper Virus Associated with a Lethal Outbreak in Monkeys Can Readily Adapt To Use Human Receptors |
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| Authors: | Kouji Sakai Tomoki Yoshikawa Fumio Seki Shuetsu Fukushi Maino Tahara Noriyo Nagata Yasushi Ami Tetsuya Mizutani Ichiro Kurane Ryoji Yamaguchi Hideki Hasegawa Masayuki Saijo Katsuhiro Komase Shigeru Morikawa Makoto Takeda |
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| Institution: | Department of Virology 3,a;Department of Virology 1,b;Department of Pathology,c;Division of Experimental Animal Research,d;Department of Veterinary Science,e National Institute of Infectious Diseases, Tokyo, Japan;Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japanf |
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| Abstract: | A canine distemper virus (CDV) strain, CYN07-dV, associated with a lethal outbreak in monkeys, used human signaling lymphocyte activation molecule as a receptor only poorly but readily adapted to use it following a P541S substitution in the hemagglutinin protein. Since CYN07-dV had an intrinsic ability to use human nectin-4, the adapted virus became able to use both human immune and epithelial cell receptors, as well as monkey and canine ones, suggesting that CDV can potentially infect humans. |
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