CD4+ T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced by Noninfectious Human Immunodeficiency Virus Type 1 Virions |
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| Authors: | A W Sylwester J-C Grivel W Fitzgerald J L Rossio J D Lifson and L B Margolis |
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| Institution: | Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1855,1. and Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC Frederick, Frederick, Maryland 21702-12012. |
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| Abstract: | We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4+ T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4+ T-cell depletion, consistent with mechanisms requiring productive infection. |
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