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S-phase and DNA-damage checkpoints: a tale of two yeasts |
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| Authors: | Elspeth Stewart Tamar Enoch |
| Institution: | Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA |
| Abstract: | Many genes required for the S-phase and DNA-damage checkpoints have been identified in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. This year many checkpoint genes have been sequenced, providing new information about the mechanism of checkpoint control. Several of these genes are conserved between the two yeasts but others are species-specific. |
| Keywords: | Abbreviations: AT ataxia telangiectasia ATMAT mutated Cdk cyclin-dependent kinase DNA-PK DNA-dependent protein kinase DSB double-stranded break PI-3 phosphatidylinositol-3 RF-C replication factor-C ssDNA single-stranded DNA |
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