Involvement of D-amino acid oxidase in elimination of free D-amino acids in mice. |
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| Authors: | Y Nagata R Konno Y Yasumura and T Akino |
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| Institution: | Department of Biochemistry, Sapporo Medical College, Japan. |
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| Abstract: | The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine. |
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