CSP介导的害虫抗药性新机制研究进展

CSPs（Chemosensory proteins）即化学感受蛋白，其在昆虫体内各个阶段均有表达，参与昆虫的多种生理过程，具有十分复杂的化学功能。CSPs基因介导昆虫抗药性是最新发现的害虫抗药性新机制，且近几年在几种昆虫中被报道。CSPs可以通过螯合作用大量结合农药，进而导致昆虫产生抗药性，但CSPs与杀虫剂的结合机理及其表达调控机制尚未被阐明。基于目前现状，本文系统综述了CSPs在昆虫抗药性中的功能以及抗药性相关酶的表达调控机制等方面的研究进展，分析其表达调控的可能机制，旨在为害虫抗药性机制研究提供新思路。

Progress in researchon the CSP mediated pest resistance new mechanisms

CSPs (Chemosensory proteins) are known as Chemosensory proteins, which are expressed at all development stages of insects and participate in a variety of insect physiological processes, with very complex chemical functions. In recent years, the phenomenon of insect resistance mediated by CSPs gene has been reported in several insect species. CSPs can bind a large number of pesticides through the sequestration, and then lead to insecticide resistance. However, the binding mechanism of CSPs to insecticides and its expression regulation mechanisms have not been clarified. This paper reviews the progress in research on the function of CSPs in insect resistance as well as the expression regulation mechanisms of resistance related enzymes, and analysis of the possible mechanisms of its expression regulation, aiming to provide theoretical basis for further study of this new mechanism of resistance.