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An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity
Authors:Nirmin Alsahafi  Nordine Bakouche  Mohsen Kazemi  Jonathan Richard  Shilei Ding  Sudipta Bhattacharyya  Durba Das  Sai Priya Anand  Jérémie Prévost  William D Tolbert  Hong Lu  Halima Medjahed  Gabrielle Gendron-Lepage  Gloria Gabrielle Ortega Delgado  Sharon Kirk  Bruno Melillo  Walther Mothes  Joseph Sodroski  James B Munro
Institution:1. Centre de Recherche du CHUM, Montreal, QC, Canada;2. Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada;3. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA;4. Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia;5. Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada;6. Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;7. Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY, USA;8. Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104-6323, USA;9. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA;10. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;11. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA;12. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA;13. Department of Medicine, Université de Montréal, Montreal, QC, Canada;14. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:HIV-1  envelope glycoproteins  State 2A  smFRET  cryo-EM  ADCC  CD4i Abs  A32  17b
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