| 胰高血糖素样肽-1与受体相互作用研究进展 |
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| 引用本文： | 聂新华,张涛,郑学仿,李元,曹洪玉,唐乾.胰高血糖素样肽-1与受体相互作用研究进展[J].生物技术通讯,2010,21(2):270-274. |
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| 作者姓名： | 聂新华 张涛 郑学仿 李元 曹洪玉 唐乾 |
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| 作者单位： | 1. 大连大学,生物工程学院,辽宁,大连,116622
2. 大连帝恩生物工程有限公司,辽宁,大连,116600;陕西省人民医院,陕西,西安,710068 |
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| 基金项目： | 国家自然科学基金，辽宁省高校创新团队项目，辽宁省教育厅项目，大连市科技计划 |
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| 摘 要： | 胰高血糖素样肽-1(GLP-1)具有促胰岛素分泌、抑制胰高血糖素分泌、刺激胰岛β细胞的增殖和分化、抑制β细胞凋亡、抑制胃排空等作用,近年来成为治疗糖尿病药物研究中的热点。GLP-1与受体的相互作用一直备受关注,我们从4个方面对GLP-1与受体相互作用的研究进行了综述:GLP-1的二级结构、GLP-1单个残基改变及残基间的相互作用、GLP-1不同残基片段对GLP-1结合并激活受体的影响和GLP-1受体的相互作用模式。
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| 关 键 词： | 胰高血糖素样肽-1 受体 相互作用 截短有效的胰高血糖素样肽-1 |
Interaction Between Glucagon-Like Peptide-1 and its Receptor |
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| NIE Xin-Hua,ZHANG Tao,ZHENG Xue-Fang,LI Yuan,CAO Hong-Yu,TANG Qian.Interaction Between Glucagon-Like Peptide-1 and its Receptor[J].Letters in Biotechnology,2010,21(2):270-274. |
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| Authors: | NIE Xin-Hua ZHANG Tao ZHENG Xue-Fang LI Yuan CAO Hong-Yu TANG Qian |
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| Institution: | NIE Xin-Hua1,ZHANG Tao1,ZHENG Xue-Fang1,LI Yuan2,3,CAO Hong-Yu1,TANG Qian1 1.College of Bioengineering,Dalian University,Dalian 116622,2.Dalian D.N Bio-Engineering Co.,Ltd,Dalian 116600,3.Shaanxi Provincial People\'s Hospital,Xi\'an 710068,China |
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| Abstract: | Glucagon-like peptide-1(GLP-1) has multifunction including increasing insulin secretion,stimulating proliferation and differentiation of pancreatic beta cells,inhibiting apoptosis of pancreatic beta cells and inhibiting gastric emptying.Recently GLP-1 has been the important drug candidate for diabetes mellitus.The interaction between GLP-1 and its receptor is always the study hotspot.This review focused on the research on the interaction between GLP-1 and its receptor in following aspects:the secondary conf... |
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| Keywords: | glucagon-like peptide-1 receptor interaction shorted and efficient glucagon-like peptide-1 |
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