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| 安徽汉族免疫性不育症与HLA-DQA1基因的相关性研究 | |
| 引用本文： | 杜华荣,王望九,余元勋,戴宁,梁文珍,黄震,申国明,马宗华,陈永华,张凯,余荣娇,洪燕.安徽汉族免疫性不育症与HLA-DQA1基因的相关性研究[J].生物技术通讯,2007,18(2):240-242. |
| 作者姓名： | 杜华荣 王望九 余元勋 戴宁 梁文珍 黄震 申国明 马宗华 陈永华 张凯 余荣娇 洪燕 |
| 作者单位： | 1. 安徽中医学院,安徽,合肥,230038 2. 安徽省医学遗传研究所,安徽,合肥,230001 3. 安徽中医学院,第一附属医院,安徽,合肥,230031 |
| 基金项目： | 安徽省自然科学基金;安徽省教育厅科研项目 |
| 摘 要： | 目的:探讨抗精子抗体阳性的免疫性不育症患者与HLA-DQA1基因的相关性。方法:采用聚合酶链反应-序列特异性引物(PCR-SSP)技术,对50例抗精子抗体阳性的免疫性不育症患者和60例正常健康者的HLA-DQA1基因进行分型研究。结果:2组均未发现DQA1I0104和DQA1I0302两种基因型。免疫性不育症组DQA1I0401等位基因频率明显高于正常对照组(RR=5.5,P<0.05)。结论:DQA1I0401可能是安徽汉族免疫性不育症的易感基因。 |
| 关 键 词： | 抗精子抗体 免疫性不育症 人类白细胞抗原 等位基因 遗传易感性 |
| 文章编号： | 1009-0002（2007）02-0240-03 |
| 修稿时间： | 2006-09-12 |
Study on the Association Between the HLA-DQA1 Alleles with Immunologic Infertility of Han Nationality in Anhui Province |
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| DU Hua-rong,WANG Wang-jiu,YU Yuan-xun,DAI Ning,LIANG Wen-zhen,HUANG Zhen,SHEN Guo-ming,MA Zong-hua,CHEN Yong-hua,ZHANG Kai,YU Rong-jiao,HONG Yan.Study on the Association Between the HLA-DQA1 Alleles with Immunologic Infertility of Han Nationality in Anhui Province[J].Letters in Biotechnology,2007,18(2):240-242. | |
| Authors: | DU Hua-rong WANG Wang-jiu YU Yuan-xun DAI Ning LIANG Wen-zhen HUANG Zhen SHEN Guo-ming MA Zong-hua CHEN Yong-hua ZHANG Kai YU Rong-jiao HONG Yan |
| Institution: | 1. Anhui Colleage of Traditional Chinese Medicine, Hefei 230038; 2. The Center of Medical Genetics of Anhui Province, Hefei 230001; 3. The First Affiliated Hospital of Anhui Colleage of Traditional Chinese Medicine, Hefei 230031; China |
| Abstract: | Objective:To explore the association between the HLA-DQA1 alleles with Immun-ologic infertility of Han nationality in Anhui Province.Methods:Polymerase chain reaction sequence specific prime(PCR-SSP)was used to type HLA-DQA1 subregion in 50 patients with immunologic infertility and 60 unrelated healthy control of Han nationality in Anhui Province.Results:The HLA DQA1*0104 and DQA1*0302 alleles in both group were not found.The allelic frequency of HLA-DQA1*0401 was significantly increased in immunologic infertility patients than in the control(RR=5.5,P<0.05).Conclusion:It suggested that the HLA-DQA1*0401 allele may be suscep-tible gene for immunologic infertility in Han nationality in Anhui Province. |
| Keywords: | antisperm antibody immunologic infertility human leukocyte antigen allele gene genetic susceptibility |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |