| Toll样受体与抗结核感染免疫 |
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| 引用本文： | 柏银兰,薛莹,徐志凯.Toll样受体与抗结核感染免疫[J].生物技术通讯,2006,17(6):961-963. |
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| 作者姓名： | 柏银兰 薛莹 徐志凯 |
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| 作者单位： | 第四军医大学,基础部微生物学教研室,陕西,西安,710032 |
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| 基金项目： | 国家自然科学基金项目(30500432) |
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| 摘 要： | 结核分枝杆菌(MTB)是结核病的致病菌,其发病机制仍未阐明。Toll样受体(TLR)蛋白家族属于动物模式识别受体家族。研究表明,TLR对先天免疫和获得性免疫都有调控作用,与抗结核感染免疫有关的主要是TLR2和TLR4。对TLR的研究为MTB诱导先天免疫反应机制的阐明以及治疗方法的进步提供了新的思路。
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| 关 键 词： | 结核分枝杆菌 Toll样受体 免疫 感染 |
| 文章编号： | 1009-0002(2006)06-0961-03 |
| 收稿时间： | 03 17 2006 12:00AM |
| 修稿时间： | 2006年3月17日 |
Toll Like Receptor and Anti-Infection Immunity to Mycobacterium tuberculosis |
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| BAI Yin-lan,XUE Ying,XU Zhi-kai.Toll Like Receptor and Anti-Infection Immunity to Mycobacterium tuberculosis[J].Letters in Biotechnology,2006,17(6):961-963. |
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| Authors: | BAI Yin-lan XUE Ying XU Zhi-kai |
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| Abstract: | Mycobacterium tuberculosis is the pathogenic bacterium of tuberculosis and its pathogenesis has not been illuminated completely. Toll like receptor (TLR) belong to animal pattern recognition receptor family. TLR can regulate both innate immunity and adaptive immunity in molecule level. TLR2 and TLR4 are two important molecules to the anti-infection immunity to M.tuberculosis. The progress on research of TLR may be useful to clarity the pathogenesis and be helpful to improve therapy research of M.tuberculosis. |
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| Keywords: | Mycobacterium tuberculosis Toll like receptor immunity infection |
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