猪源性甲型H1N1流感病毒研究概况

2009年3月在美国和墨西哥流感样患者的呼吸道标本中鉴定出新的猪源性甲型H1N1流感病毒。该病毒可人-人传播,已蔓延到112个国家和地区。为了遏制不断重组或重配的流感病毒,各国学者对甲型H1N1流感病毒的分子生物学特征、复制周期及实验室诊断做了细致的研究,以研发相应的药物或疫苗,这些成就为世界各国防控今年新鉴定的猪源性甲型H1N1流感病毒感染发挥了重要作用。现就猪源性甲型H1N1流感病毒的鉴定、基因组结构特征做一综述。

General Review in the Study on Swine-Origin Influenza A(H1N1) Virus

A novel swine-origin influenza A（H1N1） virus（S-OIV） was identified from respiratory tract specimens of patients with influenza-like symptoms on March 2009 in USA and Mexico, The virus is contagious, spreading easily from one person to another and has been reported in 112 countries and regions. The intensive study of molecular characteriza- tion and replication cycle and laboratory diagnosis for influenza A viruses were made for controlling the human pandemics of the recombinant or reassortant influenza by vaccination and the use of antiviral drugs. These achieves played an impor- tant role for countries in the world in prevention and control the new identification S-OIV in this year. The available information about the characteristics and genomic structures of the S-OIV was collected and reviewed.