| NDRG—1基因表达的影响因素 |
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| 引用本文： | 史杪,崔永峰,张强,王强,陈晓东.NDRG—1基因表达的影响因素[J].生物技术通讯,2013(4):565-567,594. |
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| 作者姓名： | 史杪 崔永峰 张强 王强 陈晓东 |
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| 作者单位： | [1]军事医学科学院疾病预防控制所,北京100071 [2]包头医学院,内蒙古包头014060 |
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| 基金项目： | 国家自然科学基金青年项目（30901170） |
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| 摘 要： | 恶性肿瘤细胞迁移是一个非常重要的临床问题，也是导致癌症患者死亡的主要原因之一。N—myc下游调节基因1（NDRG—J）是近年发现的与细胞分化相关的基因，在阻止肿瘤细胞入侵和迁移，尤其是抑制肿瘤组织生长的过程中扮演着非常重要的角色。该基因可以被多种分化调节剂诱导表达。我们就影响其表达的几个典型因素做简要综述。
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| 关 键 词： | N-myc下游调节基因1 分化调节剂 肿瘤 研究现状 |
Advances in Influencing Factors of NDRG-1 Expression |
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| SHI Miao,CUI Yong-Feng,ZHANG Qiang,WANG Qiang,CHEN Xiao-Dong.Advances in Influencing Factors of NDRG-1 Expression[J].Letters in Biotechnology,2013(4):565-567,594. |
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| Authors: | SHI Miao CUI Yong-Feng ZHANG Qiang WANG Qiang CHEN Xiao-Dong |
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| Institution: | 1. Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing 100071; 2. Baotou Medical College, Baotou 014060; China) |
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| Abstract: | Tumor metastasis is a very important clinical issue, which results from the majority of cancer-related deaths. N-myc downstream-regulated gene-l（NDRG-1）, a new tumor metastasis suppressor gene, plays an impor- tant role in preventing the invasion and migration of tumor cell, especially of inhibiting the growth of tumor tis-sue. NDRG-1 expression can be regulated by many differentiation regulators. In this review we reported the cur-rent research status of its influencing factors. |
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| Keywords: | N-myc downstream-regulated gene-1 differentiation regulators tumor research status |
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