| 基于TRAIL的肿瘤治疗策略进展 |
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| 引用本文： | 隋臻,尹帮旗,李招发.基于TRAIL的肿瘤治疗策略进展[J].生物技术通讯,2011,22(5):733-737. |
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| 作者姓名： | 隋臻 尹帮旗 李招发 |
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| 作者单位： | 1. 华侨大学分子药物学研究所,福建泉州,362021
2. 华侨大学分子药物学研究所,福建泉州362021;分子药物教育部工程研究中心,福建泉州362021 |
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| 基金项目： | 桶建省自然科学基金，福建省发改委项目 |
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| 摘 要： | 肿瘤坏死因子相关凋亡诱导配体(TRAIL)能选择性诱导肿瘤细胞凋亡,且对机体正常组织细胞无毒副作用,被认为是一种非常有潜力的抗癌药物。我们简要介绍TRAIL及其配体诱导细胞凋亡的机制、肿瘤细胞对TRAIL的耐受机制及其克服策略。
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| 关 键 词： | 肿瘤坏死因子相关凋亡诱导配体 死亡受体 耐受机制 肿瘤 |
Progress of TRAIL-Based Cancer Treatment Strategies |
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| SUI Zhen,YIN Bang-Qi,LI Zhao-Fa.Progress of TRAIL-Based Cancer Treatment Strategies[J].Letters in Biotechnology,2011,22(5):733-737. |
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| Authors: | SUI Zhen YIN Bang-Qi LI Zhao-Fa |
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| Institution: | SUI Zhen 1,YIN Bang-Qi 1,LI Zhao-Fa 1,2 1.Institue of Molecular Medicine,Huaqiao University,Quanzhou 362021,2.Molecular Medicine Engineering Research Center of Ministry of Education,China |
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| Abstract: | The tumor necrosis factor-related optosis-inducing ligand(TRAIL) can selectively induce tumor cell apoptosis without side effect on normal cells,so it was considered as a very promising anti-cancer drug.This arti-cle focused on the mechanism of apoptosis of tumor cells induced by TRAIL and its receptors,and the mechanism of tumor tolerance to TRAIL and the strategies against it. |
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| Keywords: | tumor necrosis factor-related optosis-inducing ligand death receptor tolerance mechanism cancer |
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