| 雌激素信号通路概述 |
| |
| 引用本文： | 屈超,刘中洋,袭荣刚,王晓波.雌激素信号通路概述[J].生物技术通讯,2014(3):448-450. |
| |
| 作者姓名： | 屈超 刘中洋 袭荣刚 王晓波 |
| |
| 作者单位： | [1]沈阳军区药物研究所,辽宁大连116015 [2]解放军第210医院,辽宁大连116015 |
| |
| 基金项目： | 国家重大新药创制科技重大专项（2009ZXJ09002-019） |
| |
| 摘 要： | 过去几十年,人们一直认为雌激素信号通路是雌激素与细胞核中的雌激素受体(ER)结合,作用于雌激素受体反应元件调节基因表达,从而改变细胞功能。雌激素不但与核ER结合,也能与膜ER结合激活PI3K信号通路。G蛋白偶联受体(GPR30)也能与雌激素结合,激活PI3K信号通路。雌激素通过结合不同雌激素受体改变细胞生理功能。我们对雌激素信号通路做简要综述。
|
| 关 键 词： | 雌激素 核雌激素受体 膜雌激素受体 |
Estrogen Signaling Review |
| |
| QU Chao,LIU Zhong-Yang,XI Rong-Gang,WANG Xiao-Bo.Estrogen Signaling Review[J].Letters in Biotechnology,2014(3):448-450. |
| |
| Authors: | QU Chao LIU Zhong-Yang XI Rong-Gang WANG Xiao-Bo |
| |
| Institution: | 1. Institute of Materia Medica of Shenyang Military Region, Dalian 116015; 2. The 210th Hospital of PLA, Dalian 116015; China) |
| |
| Abstract: | Until some decade ago, all estrogen signaling was thought to occur by estrogen binding to nuclear estrogen receptors. Estrogen binding to the receptor alters gene expression, thereby altering cell function. Estrogen also binds to nuclear estrogen receptors that are tethered to the plasma membrane, resulting in acute activation of signaling kinases such as PI3K. An orphan G-protein-coupled receptor, GPR30, can also bind estrogen and activate acute signaling pathways. Thus, estrogen can alter cell function by binding to different estrogen receptors. In this article we reviewed the different estrogen receptors and their signaling. |
| |
| Keywords: | estrogen nuclear estrogen receptor membrane estrogen receptor |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
