| 磷脂酰胆碱对酒精性肝病保护作用的研究进展 |
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| 引用本文： | 张媛,于喆,刘富丹,崔玉影,邹伟.磷脂酰胆碱对酒精性肝病保护作用的研究进展[J].生物技术通讯,2009,20(3):439-441. |
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| 作者姓名： | 张媛 于喆 刘富丹 崔玉影 邹伟 |
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| 作者单位： | 辽宁师范大学,生命科学学院,辽宁省生物技术与分子药物研发重点实验室,辽宁,大连,116029 |
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| 摘 要： | 酒精性肝病已逐渐成为第二大肝脏疾病,威胁着人类的健康。乙醇引发肝损伤的机制主要包括其代谢产物乙醛对肝细胞造成的毒性作用、自由基损伤及对肝脏线粒体产生的毒性作用等。已证实,磷脂酰胆碱对酒精肝损伤具有明显的保护作用。简要介绍了酒精肝病机制及磷脂酰胆碱对酒精性肝损伤的保护作用研究进展,以期为治疗酒精性肝病提供帮助。
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| 关 键 词： | 酒精性肝病 磷脂酰胆碱 保护作用 |
Advance on the Protective Effect of Phosphatidylcholine on Alcoholic Liver Disease |
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| ZHANG Yuan,YU Zhe,LIU Fu-Dan,CUI Yu-Ying,ZOU Wei.Advance on the Protective Effect of Phosphatidylcholine on Alcoholic Liver Disease[J].Letters in Biotechnology,2009,20(3):439-441. |
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| Authors: | ZHANG Yuan YU Zhe LIU Fu-Dan CUI Yu-Ying ZOU Wei |
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| Institution: | (College of Life Science, Liaoning Normal University, Key Laboratory of Biotechnology and Molecular Pharmacy in Liaoning Province, Dalian 116029, China) |
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| Abstract: | Alcoholic liver disease has gradually become the second largest liver disease threat to humanity. The mechanism of ethanol-induced hepatic injury includes the toxic effects of metabolite acetaldehyde on liver cells and free radical damage to the liver mitoehondria. The phosphatidyleholine takes the new health care medicine, was confirmed in the alcoholic liver disease protective function. The research advance of the mechanism of alcoholic liver disease and the protective effect of phosphatidyleholine were reviewed here. |
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| Keywords: | alcoholic liver disease phosphatidylcholine the protective effect |
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