| 基因工程抗体研究进展 |
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| 引用本文： | 王秀红,周素芳.基因工程抗体研究进展[J].生物技术通讯,2007,18(2):304-306. |
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| 作者姓名： | 王秀红 周素芳 |
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| 作者单位： | 广西医科大学,生物化学与分子生物学教研室,广西,南宁,530021 |
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| 摘 要： | 临床治疗中人抗鼠抗体反应的出现使鼠源性单克隆抗体的应用受到了极大的限制。为降低其免疫原性,人们利用基因工程技术对鼠源抗体进行改造,以减少其鼠源成分。简要概述了目前研究比较多的几种基因工程抗体及其临床应用。
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| 关 键 词： | 基因工程抗体 嵌合抗体 CDR移植抗体 |
| 文章编号： | 1009-0002（2007）02-0304-03 |
| 修稿时间： | 2006-08-11 |
Advances in Research on Genetically Engineered Antibody |
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| WANG Xiu-hong,ZHOU Su-fang.Advances in Research on Genetically Engineered Antibody[J].Letters in Biotechnology,2007,18(2):304-306. |
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| Authors: | WANG Xiu-hong ZHOU Su-fang |
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| Abstract: | The clinical utility of murine monoclonal antibodies has been greatly limited by the human anti-murine antibody responses.To make them less immunogenic,murine antibodies have been genetically engineered to progressively replace their murine content with that of human counterparts.In this review,some genetically engineered antibodies and their clinical applications were briefly described. |
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| Keywords: | genetically engineered antibody chimeric antibody CDR-grafted antibody |
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