| 葡激酶及其化学修饰研究进展 |
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| 引用本文： | 熊剑,董伟,李勇,王纲.葡激酶及其化学修饰研究进展[J].生物技术通讯,2003,14(3):207-209. |
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| 作者姓名： | 熊剑 董伟 李勇 王纲 |
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| 作者单位： | 南京理工大学,化工学院,南京,210094 |
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| 摘 要： | 葡激酶(SAK)是一种由金黄色葡萄球菌分泌的含有136个氨基酸残基的蛋白质，大量研究证明它具有潜在的溶血栓特性。但葡激酶是一种外源蛋白，注入体内会引起不良反应，解决这些问题的重要途径就是对蛋白质进行化学修饰。本综述SAK的结构、洛栓机理、化学修饰及临床研究等。
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| 关 键 词： | 葡激酶 化学修饰 金黄色葡萄球菌 溶血栓特性 |
| 文章编号： | 1009-0002(2003)03-0207-03 |
| 修稿时间： | 2002年11月25 |
Progress in staphylokinase and its chemical modification |
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| XIONG Jian,DONG Wei,LI Yong,WANG Gang.Progress in staphylokinase and its chemical modification[J].Letters in Biotechnology,2003,14(3):207-209. |
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| Authors: | XIONG Jian DONG Wei LI Yong WANG Gang |
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| Abstract: | Staphylokinase (SAK),secreted by certain strains of Staphylococcus aureus and produced by recombinant DNA technology,is a136-amino-acid single-chain protein without disulfide bridges.It's thrombolytic potential and fibrin specificity were demonstrated only few years ago,and many clinical trials demonstrated that SAK would be a promising thrombolytic reagent.But such problems as strong immunogenicity,short circulatory half-life make it in-valid in clinical use.One way to solve these problems is to modify it with polyethylene glycol(PEG).This review in-troduced the structure and thrombolytic mechanism of SAK,SAK's peglation and clinical research concerned. |
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| Keywords: | staphylokinase thrombolytic modification polyethylene glycol |
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