| 噬菌体抗体库研究进展 |
| |
| 引用本文： | 杜威世,孙志伟,俞炜源.噬菌体抗体库研究进展[J].生物技术通讯,2006,17(2):255-257. |
| |
| 作者姓名： | 杜威世 孙志伟 俞炜源 |
| |
| 作者单位： | 军事医学科学院,生物工程研究所,北京,100071 |
| |
| 基金项目： | 国家重点基础研究发展规划项目(2002CB513205) |
| |
| 摘 要： | 治疗性抗体的发展经历了异源抗体、人源化抗体和人源性抗体几个阶段。目前,人源性抗体是治疗性抗体发展的主要方向,而噬菌体抗体库技术的出现为人源性抗体的制备提供了良好的技术平台,并且逐渐成为目前获得人源性抗体的主要手段之一。噬菌体抗体库技术是20世纪90年代初期抗体工程领域的一项重大进展,它是噬菌体展示和抗体库2种技术的集成,目前广泛应用于生物医学领域。本文对该技术的原理、类型、特点及研究进展进行了综述。
|
| 关 键 词： | 噬菌体展示 抗体库 |
| 文章编号： | 1009-0002（2006）02-0255-03 |
| 收稿时间： | 2005-12-23 |
| 修稿时间： | 2005年12月23 |
Advance in Phage Display Antibody Library |
| |
| DU Wei-shi,SUN Zhi-wei,YU Wei-yuan.Advance in Phage Display Antibody Library[J].Letters in Biotechnology,2006,17(2):255-257. |
| |
| Authors: | DU Wei-shi SUN Zhi-wei YU Wei-yuan |
| |
| Abstract: | The progress of the therapeutic antibody had gone though heterogonous antibodies, humanized, antibodies and human antibodies. The human antibody is the mainly progress direction of the therapeutic antibody. The phage display antibody library technology is a good platform for the produce of human antibodies. It has become one of main methods to obtain the human antibody. The phage display antibody library technology is a great progress in the area of antibody engineering in the forepart of 1990s. It is integration of phage display and antibody library. Now, it has been applied widely in biomedicine. The elements, classification and the further research of the technology were summarized in this paper. |
| |
| Keywords: | phage display antibody library |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
