| Tie2受体研究进展及其在抗肿瘤治疗中的应用 |
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| 引用本文： | 廖振林,侯利华,陈薇,童贻刚.Tie2受体研究进展及其在抗肿瘤治疗中的应用[J].生物技术通讯,2004,15(4):383-385. |
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| 作者姓名： | 廖振林 侯利华 陈薇 童贻刚 |
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| 作者单位： | 军事医学科学院,微生物流行病研究所,北京,100071 |
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| 基金项目： | 北京市自然科学基金项目(5022012) |
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| 摘 要： | Tie2是胚胎血管发育和肿瘤血管形成都需要的内皮细胞酪氨酸激酶受体，血管生成素(Ang)是其配体。正常成人组织中，Ang／Tie2受体水平较低，用于维持成熟的血管结构；一般癌组织中Ang／Tie2的表达较为活跃。本综述了Ang／Tie2的结构和功能研究的最新进展，Ang／Tie2在血管形成中的重要调节作用，以及可溶性Tie2在治疗肿瘤方面的前景。
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| 关 键 词： | Tie2 受体 血管生成素 肿瘤 调节作用 治疗 |
| 文章编号： | 1009-0002(2004)04-0383-03 |
| 修稿时间： | 2003年12月4日 |
Research advances in Tie2 receptor and its use in anti-tumor treatment |
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| LIAO Zhen-lin,HOU Li-hua,CHEN Wei,TONG Yi-gang Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing,China.Research advances in Tie2 receptor and its use in anti-tumor treatment[J].Letters in Biotechnology,2004,15(4):383-385. |
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| Authors: | LIAO Zhen-lin HOU Li-hua CHEN Wei TONG Yi-gang Institute of Microbiology and Epidemiology Academy of Military Medical Sciences Beijing China |
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| Institution: | LIAO Zhen-lin,HOU Li-hua,CHEN Wei,TONG Yi-gang Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing100071,China |
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| Abstract: | Tie2is an endothelial receptor tyrosine kinase that is required for both normal embryonic vascular development and tumor angiogenesis.Angiopoietin is its ligand.In normal adult tissue,the expression level of Ang /Tie2only can maintain mature vasculature,but in tumor tissue,it can achieve a high level.The last research advances about Ang /Tie2structure and function,Ang /Tie2modulating function in angiogenesis and using soluble Tie2to treat tumor,are mainly de-scribed in this paper. |
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| Keywords: | Tie2 receptor angiopoietin tumor |
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