| 整联蛋白与其配体结合的分子机制研究进展 |
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| 引用本文： | 赵建勇,高闪电,独军政,常惠芸.整联蛋白与其配体结合的分子机制研究进展[J].生物技术通讯,2008,19(6):916-918. |
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| 作者姓名： | 赵建勇 高闪电 独军政 常惠芸 |
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| 作者单位： | 中国农业科学院,兰州兽医研究所,国家口蹄疫参考实验室,家畜疫病痛原生物学国家重点实验室,农业部畜禽病毒学重点开放实验室,甘肃,兰州,730046 |
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| 摘 要： | 整联蛋白是细胞表面的主要膜受体,具有介导细胞与细胞基质间的黏附及病毒吸附细胞等功能。αⅠ结构域型整联蛋白和非αⅠ结构域型整联蛋白与配体结合的方式各异。对整联蛋白-配体复合物分子结构的研究表明,整联蛋白利用其配体结合位点的αMIDAS（依赖金属离子的吸附位点）、βMIDAS与各种类型配体结合。
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| 关 键 词： | 整联蛋白 受体 配体 依赖金属离子的吸附位点 |
Development of Molecular Mechanisms of Integrins Binding Their Ligands |
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| ZHAO Jian-Yong,GAO Shan-Dian,DU Jun-Zheng,CHANG Hui-Yun.Development of Molecular Mechanisms of Integrins Binding Their Ligands[J].Letters in Biotechnology,2008,19(6):916-918. |
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| Authors: | ZHAO Jian-Yong GAO Shan-Dian DU Jun-Zheng CHANG Hui-Yun |
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| Institution: | ( Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology, Na- tional FMD Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China) |
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| Abstract: | Integrins are major cell membrane receptors, which mediate cell-extracellular matrix adhesion and virus ab- sorption onto cells. I domain or non- I domain of integrin binding ligand is found in integrin-ligand complex. Nowdays, studies in the molecular biological characteristic of the complex reveal that integrins use the binding-site αMIDAS or βMIDAS binding different ligands. Molecular mechanisms of integrins receptor binding ligand are reviewed in this paprer. |
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| Keywords: | integrin receptor ligand metal ion dependent adhesion site |
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