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| 水母雪莲细胞培养物调血脂作用的初步研究 | |
| 引用本文： | 杨波,李天德,胡显文,王劲松,高丽华,陈惠鹏.水母雪莲细胞培养物调血脂作用的初步研究[J].生物技术通讯,2005,16(1):46-47. |
| 作者姓名： | 杨波 李天德 胡显文 王劲松 高丽华 陈惠鹏 |
| 作者单位： | 1. 军事医学科学院,生物工程研究所,北京,100071;解放军总医院,心内科,北京,100853 2. 解放军总医院,心内科,北京,100853 3. 军事医学科学院,生物工程研究所,北京,100071 |
| 摘 要： | 为研究水母雪莲细胞培养物对高脂大鼠的调血脂作用，将雄性SD大鼠分为4组：正常对照组(A组)、高脂模型组(B组)、高剂量组(C组)和低剂量组(D组)。A组喂基础饲料，B组喂高脂饲料，C组喂高脂饲料的同时饲以大剂量水母雪莲细胞培养物，D组喂高脂饲料的同时饲以小剂量水母雪莲细胞培养物。给药1/d，3周后采血，测定血脂水平及肝肾功能。C组较B组各项血脂指标均有改善，各组间肝肾功能未见显性差异。初步研究表明，水母雪莲细胞培养物对高脂大鼠具有调血脂的作用。本实验用药剂量安全。 |
| 关 键 词： | 水母雪莲 细胞培养物 高血脂大鼠 调血脂作用 |
| 文章编号： | 1009-0002(2005)01-0046-02 |
| 修稿时间： | 2004年7月15日 |
The Blood Lipid Regulating Effects of the Cell Cultures of Saussurea medusa:a Preliminary Study |
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| YANG Bo,LI Tian-de,HU Xian-wen,WANG Jin-song,GAO Li-hua,CHEN Hui-peng.The Blood Lipid Regulating Effects of the Cell Cultures of Saussurea medusa:a Preliminary Study[J].Letters in Biotechnology,2005,16(1):46-47. | |
| Authors: | YANG Bo LI Tian-de HU Xian-wen WANG Jin-song GAO Li-hua CHEN Hui-peng |
| Institution: | YANG Bo1,2,LI Tian-de2,HU Xian-wen1,WANG Jin-song2,GAO Li-hua1,CHEN Hui-peng11. Institute of Biotechnology,Academy of Military Medical Sciences,Beijing 100071,2. Cardiology Department,PLA General Hospital,Beijing 100853,China |
| Abstract: | To investigate the blood lipid regulating effects of the cell cultures of Saussurea medusa(CCSM) on hyperlipidemic rats, SD male rats were divided into four groups: control group(group A), hyperlipidemic model group(group B), high dose group(group C), low dose group(group D). Group A was only fed with basic diet. Group B was fed with high fatty diet. Group C was fed with high fatty diet associated with high dose CCSM. Group D was fed with high fatty diet associated with low dose CCSM. CCSM was given once a day. Three weeks later, the blood samples were taken for the evaluation of blood lipid levels and the functions of liver and renal. The blood lipid indexes of group C were better than those of group B. No significant difference was found in the liver and renal functions. The present study showed that CCSM has blood lipid regulating effects on hyperlipidemic rats. The dose usage in this study is safe. |
| Keywords: | Saussurea medusa cell culture rats hyperlipidemia |
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