ABC细胞膜转运蛋白及其介导的细胞多药耐药研究进展

ABC细胞膜转运蛋白是一个能转运多种底物的蛋白质家族,其在宿主对异物的防御机制和肿瘤细胞对抗癌药物的耐药性中发挥重要作用。ABC转运蛋白能将已进人细胞的外源性物质从胞内泵出胞外,是造成肿瘤细胞多药耐药的主要原因,其基因表达水平与细胞内药物浓度和耐药程度密切相关。近年来,肿瘤细胞多药耐药性研究炙手可热。我们简要综述ABC细胞膜转运蛋白的特点、分布、表达及其介导的细胞多药耐药方面的研究进展。

Advancement of Multidrug Resistance Induced by ABC Transporters

ABC transporters are a class of membrane transport proteins which can transport a variety of sub？strates. ABC transporters play an pivital role in the host defense mechanism and tumor cell resistance to antican？cer drugs. Since ABC transporters can pump intra-cellular exogenous substances to the extracellular enviroment, it is considered the main reason responsible for the multidrug resistance of tumor cells. Which is more, the intracel？lular drug concentration and the drug resistance degree were closely related to the gene expression level of ABC transporters. In recent years, the study of multi-drug resistant tumor cells became a hotspot, a lot of experiments research has been accomplished by domestic and foreign scholars on the multidrug resistance of tumor cells in？duced by ABC transporters. This paper briefly reviewed the characteristics, distribution, expression, and some prog？ress of ABC transporters with regard to tumor multidrug resistance.