| 肝细胞生长因子抗肾纤维化研究进展 |
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| 引用本文： | 陈杏,张庆林,熊锡山,王汉斌.肝细胞生长因子抗肾纤维化研究进展[J].生物技术通讯,2011,22(3):449-452. |
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| 作者姓名： | 陈杏 张庆林 熊锡山 王汉斌 |
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| 作者单位： | 1. 军事医学科学院附属医院肾内科,北京,100071
2. 放射与辐射医学研究所,北京,100850 |
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| 摘 要： | 慢性肾脏疾病患者的肾功能会随时间的推移而进行性恶化,肾实质细胞进行性丧失及细胞外基质蛋白过度沉积将导致肾纤维化形成,肾纤维化进行性发展将最终走向终末期肾衰竭。肝细胞生长因子(HGF)及其受体c-Met对肾发育和急性肾损伤后的肾脏再生修复具有重要作用,在慢性肾衰竭及肾纤维化时,HGF还具有营养肾脏及抗肾纤维化的作用。简要综述了HGF抑制肾纤维化形成的细胞分子机制的研究进展,提示HGF在治疗肾纤维化方面所具有的前景。
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| 关 键 词： | 肝细胞生长因子 肾脏疾病 纤维化 |
Advances of Hepatocyte Growth Factor as an Anti-Fibrotic Regulator in Renal Disease |
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| CHEN Xing,ZHANG Qing-Lin,XIONG Xi-Shan,WANG Han-Bin.Advances of Hepatocyte Growth Factor as an Anti-Fibrotic Regulator in Renal Disease[J].Letters in Biotechnology,2011,22(3):449-452. |
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| Authors: | CHEN Xing ZHANG Qing-Lin XIONG Xi-Shan WANG Han-Bin |
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| Institution: | 1 a.Department of Nephrology,Affiliated Hospital,Beijing 100071;b.Institute of Radiation Medicine,Beijing 100850;Academy of Military Medical Sciences,China |
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| Abstract: | The renal function of patients suffered from chronic kidney disease shows a progressive decline over time.The pathogenesis of renal fibrosis is a progressive process,which is characterized by the progressive loss of renal parenchymal cells and an excessive accumulation of extracellular matrix,that ultimately leads to end-stage renal failure.Hepatocyte growth factor（HGF） and c-Met/HGF receptor play roles in kidney development and regeneration after acute renal injury.As to chronic renal failure and renal fibrosis,HGF also acts an nutritional and anti-fibrotic factor.The mini-review attempts to highlight the recent progress in our understanding of the cellular and molecular pathways by which HGF plays a role in anti-fibrosis,indicating the challenges and opportunities in developing therapeutic strategies. |
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| Keywords: | hepatocyte growth factor renal disease fibrosis |
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