抗血管生成蛋白与多肽研究进展

多项动物实验和临床实啦已经充分证实，抗血管生成疗法可以抑制肿瘤生长。在可抑制肿瘤生长的分子中，许多是蛋白与多肽，包括细胞因子、趋化因子、血管内皮生长因子及其受体的抗体、可溶性受体、胞外基质蛋白片段及小分子合成多肽等。简要综述其中部分分子的作用机理及临床应用情况。

Advances in Antiangiogenic Peptides and Proteins

Tumor growth can be suppressed by inhibition of tumor angiogenesis in many experimental models and clinical trials. Among the antiangiogenic molecules reported to date many are peptides and proteins. They include cytokines, chemokines, antibodies to vascular growth factors and growth factor receptors, soluble receptors, fragments derived from extracellular matrix proteins and small synthetic peptides. In this article, some of these molecules were reviewed and their mechanism of action and their potential therapeutic use as anticancer agents in humans were discussed.