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| 几种差异序列分析方法的比较及其研究前景 | |
| 引用本文： | 李敏惠,杨平,曹月青.几种差异序列分析方法的比较及其研究前景[J].生物技术通讯,2006,17(6):1008-1010. |
| 作者姓名： | 李敏惠 杨平 曹月青 |
| 作者单位： | 1. 成都医学院,科研实验中心,四川,成都,610083 2. 成都医学院,生物化学教研室,四川,成都,610083 3. 重庆大学,生物工程学院基因工程研究中心,重庆,400044 |
| 摘 要： | 分离和鉴定不同生物基因的差异序列,有助于功能基因的分离,揭开物种间进化的规律,阐明某些疾病相关基因的作用机理。本文简述了几种近年来常用的筛选差异基因的方法,特别是最新发表的杂交监控差异分析法(HMDA)的原理、适用范围及其特点,重点探讨了HMDA法在真核基因组差异序列筛选中的技术性突破及其研究前景。 |
| 关 键 词： | 基因组 差异序列 杂交监控差异分析法 |
| 文章编号： | 1009-0002(2006)06-1008-03 |
| 收稿时间： | 02 23 2006 12:00AM |
| 修稿时间： | 2006年2月23日 |
Comparison and Research of Several Analytic Methods on the Genic Differences |
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| LI Min-hui,YANG Ping,CAO Yue-qing.Comparison and Research of Several Analytic Methods on the Genic Differences[J].Letters in Biotechnology,2006,17(6):1008-1010. | |
| Authors: | LI Min-hui YANG Ping CAO Yue-qing |
| Institution: | 1. Science Research Center;, 2. Biochemistry Department, Chengdu Medical College, Chengdu 610083; 3. Genetic Engineering Research Center of Bioengineering Institute, Chongqing University, Chongqing 400044; China |
| Abstract: | The separation and identification of genic differences will be helpful for obtaining the functional genes, unveiling the evolutionary rule of species and elucidating the mechanism of those genes related to diseases. The principles, applicability and compare of their advantages and disadvantages of several analytic methods on the genic differences, especially a new method called hybridization-monitored differential analysis, HMDA were briefly reviewed in this paper. The technique breakthrough and research foreground on genomic differences with HMDA were also discussed. |
| Keywords: | genome genic differences hybridization-monitored differential analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |