The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue |
| |
Authors: | Joana RF Abreu Daphne de Launay Marjolein E Sanders Aleksander M Grabiec G Marleen van de Sande Paul P Tak Kris A Reedquist |
| |
Institution: | (1) Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands |
| |
Abstract: | Introduction Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients share many similarities with transformed cancer
cells, including spontaneous production of matrix metalloproteinases (MMPs). Altered or chronic activation of proto-oncogenic
Ras family GTPases is thought to contribute to inflammation and joint destruction in RA, and abrogation of Ras family signaling
is therapeutic in animal models of RA. Recently, expression and post-translational modification of Ras guanine nucleotide
releasing factor 1 (RasGRF1) was found to contribute to spontaneous MMP production in melanoma cancer cells. Here, we examine
the potential relationship between RasGRF1 expression and MMP production in RA, reactive arthritis, and inflammatory osteoarthritis
synovial tissue and FLS. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|