Gene profiling for defining targets for new therapeutics in autoimmune diseases |
| |
Authors: | Email author" target="_blank">Lars?RoggeEmail author |
| |
Institution: | (1) Immunoregulation Laboratory, Department of Immunology, Institut Pasteur, Paris, France |
| |
Abstract: | The identification of novel targets for improved diagnosis and pharmaceutical intervention is of critical importance for better
treatment of autoimmune diseases in the future. The possibility to measure levels of gene expression for tens of thousands
of genes simultaneously and in a quantitative fashion will greatly enhance our knowledge of genes and pathways involved in
disease pathogenesis. Initial studies have focused on the gene expression profiling of homogeneous cell populations. Genomic-scale
gene expression profiling has also more recently been applied to tissue samples from patients with immunopathologies. The
scope of the present review is to discuss recent progress in this field with respect to the identification of novel target
molecules. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |